Increased circulating level of interleukin-6 and CD8⁺ T cell exhaustion are associated with progression of COVID-19.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) is pandemic. It is critical to identify COVID-19 patients who are most likely to develop a severe disease. This study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease progression.

Methods

Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing, China from December 27, 2019 to March 12, 2020 were enrolled in this study and followed-up to March 16, 2020. Differences in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by the χ² test or the Fisher exact test (categorical variables) and indep

SUBMITTER: Yang PH 

PROVIDER: S-EPMC7686818 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature