Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders.

ABSTRACT: The physiological characteristics of Andean natives living at high altitudes have been investigated extensively, with many studies reporting that Andean highlanders have a higher hemoglobin (Hb) concentration than other highlander populations. It has previously been reported that positive natural selection has acted independently on the egl-9 family hypoxia inducible factor 1 (EGLN1) gene in Tibetan and Andean highlanders and is related to Hb concentration in Tibetans. However, no study has yet revealed the genetic determinants of Hb concentration in Andeans even though several single-nucleotide polymorphisms (SNPs) in EGLN1 have previously been examined. Therefore, we explored the relationship between hematological measurements and tag SNPs designed to cover the whole EGL

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC7686849 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature