Anatomical and functional changes in the retina in patients with Alzheimer's disease and mild cognitive impairment.

ABSTRACT:

Purpose

There is evidence that mild cognitive impairment (MCI) or Alzheimer's disease (AD) is accompanied by alterations in the retina. The current study was performed to investigate structural and functional changes in patients with systemic neurodegenerative disease.

Methods

A total of 47 patients with either MCI or AD and 43 healthy age- and sex-matched control subjects were included. Inclusion criteria for MCI were abnormal memory function and a mini-mental state examination (MMSE) score >26 points, for patients with AD a diagnosis of probable AD of mild to moderate degree and an MMSE score in the range of 20-26. Retinal blood flow was measured using a Doppler optical coherence tomography (OCT) system. Retinal vessel diameter, oxygen saturation and flicker-induced vasodi

SUBMITTER: Szegedi S 

PROVIDER: S-EPMC7687124 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature