Endobronchial coils for emphysema: Dual mechanism of action on lobar residual volume reduction.

ABSTRACT:

Background and objective

The RENEW trial demonstrated that bronchoscopic lung volume reduction using endobronchial coils improves quality of life, pulmonary function and exercise performance. In this post hoc analysis of RENEW, we examine the mechanism of action of endobronchial coils that drives improvement in clinical outcomes.

Methods

A total of 78 patients from the RENEW coil-treated group who were treated in one or both lobes that were deemed as the most destroyed were included in this retrospective analysis. Expiratory and inspiratory HRCT scans were used to assess lobar volume change from baseline to 12 months post coil treatment in treated and untreated lobes.

Results

Reduction in lobar RV in treated lobes was significantly associated with favourable clinical

SUBMITTER: Hartman JE 

PROVIDER: S-EPMC7687244 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature