Multiple convergent hypothalamus-brainstem circuits drive defensive behavior.

ABSTRACT: The hypothalamus is composed of many neuropeptidergic cell populations and directs multiple survival behaviors, including defensive responses to threats. However, the relationship between the peptidergic identity of neurons and their roles in behavior remains unclear. Here, we address this issue by studying the function of multiple neuronal populations in the zebrafish hypothalamus during defensive responses to a variety of homeostatic threats. Cellular registration of large-scale neural activity imaging to multiplexed in situ gene expression revealed that neuronal populations encoding behavioral features encompass multiple overlapping sets of neuropeptidergic cell classes. Manipulations of different cell populations showed that multiple sets of peptidergic neurons play similar behavioral

SUBMITTER: Lovett-Barron M 

PROVIDER: S-EPMC7687349 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature