Cortical Observation by Synchronous Multifocal Optical Sampling Reveals Widespread Population Encoding of Actions.

ABSTRACT: To advance the measurement of distributed neuronal population representations of targeted motor actions on single trials, we developed an optical method (COSMOS) for tracking neural activity in a largely uncharacterized spatiotemporal regime. COSMOS allowed simultaneous recording of neural dynamics at ∼30 Hz from over a thousand near-cellular resolution neuronal sources spread across the entire dorsal neocortex of awake, behaving mice during a three-option lick-to-target task. We identified spatially distributed neuronal population representations spanning the dorsal cortex that precisely encoded ongoing motor actions on single trials. Neuronal correlations measured at video rate using unaveraged, whole-session data had localized spatial structure, whereas trial-averaged data exhibited wid

SUBMITTER: Kauvar IV 

PROVIDER: S-EPMC7687350 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature