Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro.

ABSTRACT: Pandemic spread of emerging human pathogenic viruses, such as the current SARS-CoV-2, poses both an immediate and future challenge to human health and society. Currently, effective treatment of infection with SARS-CoV-2 is limited and broad spectrum antiviral therapies to meet other emerging pandemics are absent leaving the World population largely unprotected. Here, we have identified distinct members of the family of polyether ionophore antibiotics with potent ability to inhibit SARS-CoV-2 replication and cytopathogenicity in cells. Several compounds from this class displayed more than 100-fold selectivity between viral-induced cytopathogenicity and inhibition of cell viability, however the compound X-206 displayed >500-fold selectivity and was furthermore able to inhibit viral replicati

SUBMITTER: Svenningsen EB 

PROVIDER: S-EPMC7687369 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature