MetaTropismDB: a database of organ-specific metastasis induced by human cancer cell lines in mouse models.

ABSTRACT: The organotropism is the propensity of metastatic cancer cells to colonize preferably certain distant organs, resulting in a non-random distribution of metastases. In order to shed light on this behaviour, several studies were performed by the injection of human cancer cell lines into immunocompromised mouse models. However, the information about these experiments is spread in the literature. For each xenograft experiment reported in the literature, we annotated both the experimental conditions and outcomes, including details on inoculated human cell lines, mouse models, injection methods, sites of metastasis, organs not colonized, rate of metastasis, latency time, overall survival and the involved genes. We created MetaTropismDB, a freely available database collecting hand-curated data us

SUBMITTER: Giulietti M 

PROVIDER: S-EPMC7687678 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature