DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.

ABSTRACT:

Background

DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits.

Methods

We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in

SUBMITTER: Vehmeijer FOL 

PROVIDER: S-EPMC7687793 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature