Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway.

ABSTRACT:

Background

Mesenchymal stem cells (MSC) are non-haematopoietic, fibroblast-like multipotent stromal cells. In the injured pancreas, these cells are assumed to secrete growth factors and immunomodulatory molecules, which facilitate the regeneration of pre-existing β-cells. However, when MSC are delivered intravenously, their majority is entrapped in the lungs and does not reach the pancreas. Therefore, the aim of this investigation was to compare the regenerative support of hTERT-MSC (human telomerase reverse transcriptase mesenchymal stem cells) via intrapancreatic (IPR) and intravenous route (IVR).

Methods

hTERT-MSC were administered by IPR and IVR to 50% pancreatectomized NMRI nude mice. After eight days, blood glucose level, body weight, and residual pancreatic weight wer

SUBMITTER: Khatri R 

PROVIDER: S-EPMC7687794 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature