Networks of High Aspect Ratio Particles to Direct Colloidal Assembly Dynamics and Cellular Interactions.

ABSTRACT: Injectable colloids that self-assemble into three-dimensional networks are promising materials for applications in regenerative engineering, as they create open systems for cellular infiltration, interaction, and activation. However, most injectable colloids have spherical morphologies, which lack the high material-biology contact areas afforded by higher aspect ratio materials. To address this need, injectable high aspect ratio particles (HARPs) were developed that form three-dimensional networks to enhance scaffold assembly dynamics and cellular interactions. HARPs were functionalized for tunable surface charge through layer-by-layer electrostatic assembly. Positively charged Chitosan-HARPs had improved particle suspension dynamics when compared to spherical particles or negatively charg

SUBMITTER: Finbloom JA 

PROVIDER: S-EPMC7687842 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature