DNA polymerase epsilon is required for heterochromatin maintenance in Arabidopsis.

ABSTRACT:

Background

Chromatin organizes DNA and regulates its transcriptional activity through epigenetic modifications. Heterochromatic regions of the genome are generally transcriptionally silent, while euchromatin is more prone to transcription. During DNA replication, both genetic information and chromatin modifications must be faithfully passed on to daughter strands. There is evidence that DNA polymerases play a role in transcriptional silencing, but the extent of their contribution and how it relates to heterochromatin maintenance is unclear.

Results

We isolate a strong hypomorphic Arabidopsis thaliana mutant of the POL2A catalytic subunit of DNA polymerase epsilon and show that POL2A is required to stabilize heterochromatin silencing genome-wide, likely by preventing replicat

SUBMITTER: Bourguet P 

PROVIDER: S-EPMC7687843 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature