Experimental Single-Platform Approach to Enhance the Functionalization of Magnetically Targetable Cells.

ABSTRACT: Magnetic guidance shows promise as a strategy for improving the delivery and performance of cell therapeutics. However, clinical translation of magnetically guided cell therapy requires cell functionalization protocols that provide adequate magnetic properties in balance with unaltered cell viability and biological function. Existing methodologies for characterizing cells functionalized with magnetic nanoparticles (MNP) produce aggregate results, both distorted and unable to reflect variability in either magnetic or biological properties within a preparation. In the present study, we developed an inverted-plate assay allowing determination of these characteristics using a single-platform approach, and applied this method for a comparative analysis of two loading protocols providing highly

SUBMITTER: Battig MR 

PROVIDER: S-EPMC7687866 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature