Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle.

ABSTRACT: FGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely to be spatially restricted and temporally dynamic throughout inner ear development. We evaluated these characteristics using genetic labeling mediated by Fgf8^mcm gene-targeted mice and determined that Fgf8 expression is a specific and early marker of Type-I vestibular hair cell identity. Fgf8^mcm expression initiates at E11.5 in the future striolar region of the utricle, labeling hair cells following EdU birthdating, and demonstrates that sub-type identity is determined shortly after terminal mitosis. This

SUBMITTER: Ratzan EM 

PROVIDER: S-EPMC7687870 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature