Conserved epitopes with high HLA-I population coverage are targets of CD8⁺ T cells associated with high IFN-γ responses against all dengue virus serotypes.

ABSTRACT: Cytotoxic CD8⁺ T cells are key for immune protection against viral infections. The breadth and cross-reactivity of these responses are important against rapidly mutating RNA viruses, such as dengue (DENV), yet how viral diversity affect T cell responses and their cross-reactivity against multiple variants of the virus remains poorly defined. In this study, an integrated analysis was performed to map experimentally validated CD8⁺ T cell epitopes onto the distribution of DENV genome sequences across the 4 serotypes worldwide. Despite the higher viral diversity observed within HLA-I restricted epitopes, mapping of 609 experimentally validated epitopes sequences on 3985 full-length viral genomes revealed 19 highly conserved epitopes across the four serotypes within the im

SUBMITTER: Adikari TN 

PROVIDER: S-EPMC7687909 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature