Multi-level assessment of obsessive-compulsive disorder (OCD) reveals relations between neural and neurochemical levels.

ABSTRACT:

Background

While considerable progress has been made in exploring the psychological, the neural, and the neurochemical dimensions of OCD separately, their interplay is still an open question, especially their changes during psychotherapy.

Methods

Seventeen patients were assessed at these three levels by psychological questionnaires, fMRI, and venipuncture before and after inpatient psychotherapy. Seventeen controls were scanned at comparable time intervals. First, pre/post treatment changes were investigated for all three levels separately: symptom severity, whole-brain and regional activity, and the concentrations of cortisol, serotonin, dopamine, brain-derived neurotrophic factor (BDNF), and immunological parameters (IL-6, IL-10, TNFα). Second, stepwise linear modeling was

SUBMITTER: Viol K 

PROVIDER: S-EPMC7687999 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature