Evaluation of metronomic chemotherapy response using diffusion and dynamic contrast-enhanced MRI.

ABSTRACT:

Purpose

To investigate the feasibility of using diffusion MRI (dMRI) and dynamic contrast-enhanced (DCE) MRI to evaluate the treatment response of metronomic chemotherapy (MCT) in the 4T1 mammary tumor model of locally advanced breast cancer.

Methods

Twelve Balb/c mice with metastatic breast cancer were divided into treated and untreated (control) groups. The treated group (n = 6) received five treatments of anti-metabolite agent 5-Fluorouracil (5FU) in the span of two weeks. dMRI and DCE-MRI were acquired for both treated and control groups before and after MCT. Immunohistochemically staining and measurements were performed after the post-MRI measurements for comparison.

Results

The control mice had significantly (p<0.005) larger tumors than the MCT treated mice. The

SUBMITTER: Baboli M 

PROVIDER: S-EPMC7688103 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature