Disuse-Induced Muscle Loss and Rehabilitation: The National Aeronautics and Space Administration Bed Rest Study.

ABSTRACT:

Objectives

The time course and magnitude of atrophic remodeling and the effects of an acute rehabilitation program on muscle atrophy are unclear. We sought to characterize bed rest-induced leg muscle atrophy and evaluate the safety and efficacy of an acute rehabilitation program.

Design

Prespecified analysis of a randomized controlled trial.

Setting

Single-center urban hospital.

Patients

Adults (24-55 yr) randomized to 70 days of sedentary bed rest.

Interventions

The 11-day post-bed rest rehabilitation program consisted of low intensity exercise and progressed to increased aerobic exercise duration, plyometric exercises, and higher intensity resistance exercise.

Measurements and main results

Upper (rectus femoris, vastus lateralis, quadriceps, ham

SUBMITTER: Scott JM 

PROVIDER: S-EPMC7688251 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature