Effects of 5-HT_2A receptor stimulation on economic demand for fentanyl after intermittent and continuous access self-administration in male rats.

ABSTRACT: The relative value of and motivation for abused drugs often increases with drug experience and differs based on drug availability. Here, we determined how different intake patterns of fentanyl, a μ-opioid agonist, alter economic demand for fentanyl and how 5-HT_2A receptor stimulation affects economic demand for fentanyl. We used a within-session demand threshold procedure to characterize changes in economic demand for fentanyl before and after intermittent or continuous access schedules. We subsequently tested the acute effects of 5-HT_2A receptor stimulation with psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on economic demand for fentanyl. Extended fentanyl experience with both intermittent and continuous schedules increased fentanyl consumption at low cost (Q

SUBMITTER: Martin DA 

PROVIDER: S-EPMC7688480 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature