Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy.

ABSTRACT: The development of cancer is not just the growth and proliferation of a single transformed cell, but its surrounding environment also coevolves with it. Indeed, successful cancer progression depends on the ability of the tumor cells to develop a supportive tumor microenvironment consisting of various types of stromal cells. The interactions between the tumor and stromal cells are bidirectional and mediated through a variety of growth factors, cytokines, metabolites, and other biomolecules secreted by these cells. Tumor-stromal crosstalk creates optimal conditions for the tumor growth, metastasis, evasion of immune surveillance, and therapy resistance, and its targeting is being explored for clinical management of cancer. Natural agents from plants and marine life have been at the forefront

SUBMITTER: Zubair H 

PROVIDER: S-EPMC7688484 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature