Tumor Infiltrating Effector Memory Antigen-Specific CD8⁺ T Cells Predict Response to Immune Checkpoint Therapy.

ABSTRACT: Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8⁺ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. We tracked tumor antigen-specific CTL frequencies and phenotype before and after ICT in responding and non-responding animals. Tumor antigen-specific CTLs increased within tumor and draining lymph nodes after ICT, and exhibited an effector memory-like phenotype, expressing IL-7R (CD127), KLRG1, T-bet, and granzyme B. Responding tumors exhibited higher infiltration of effector memory tumor ant

SUBMITTER: Principe N 

PROVIDER: S-EPMC7688517 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature