Real-world evaluation of the impact of statin intensity on adherence and persistence to therapy: A Scottish population-based study.

ABSTRACT:

Aim

To assess associations between statin intensity and adherence, persistence and discontinuation of statin therapy in Scotland.

Method

Retrospective cohort study, using linked electronic health records covering a period from January 2009 to December 2016. The study cohort included adult patients (≥18 years) newly initiating statins within Greater Glasgow and Clyde, Scotland. Study outcomes comprised adherence, discontinuation and persistence to treatment, stratified by three exposure groups (high, moderate and low intensity). Discontinuation and persistence were calculated using the refill-gap and anniversary methods, respectively. Proportion of days covered (PDC) was used as a proxy for adherence. Kaplan-Meier survival curves and Cox proportional hazard models were used t

SUBMITTER: Rezende Macedo do Nascimento RC 

PROVIDER: S-EPMC7688536 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature