A pharmacokinetic-pharmacodynamic study of a single dose of febuxostat in healthy subjects.

ABSTRACT:

Aims

To examine the pharmacokinetic-phamacodynamic (PK-PD) relationships of plasma febuxostat and serum urate and the effect of a single dose of the drug on renal excretion and fractional clearance of urate (FCU).

Methods

Blood and urine samples were collected at baseline and up to 145 hours following administration of febuxostat (80 mg) to healthy subjects (n = 9). Plasma febuxostat and serum and urinary urate and creatinine concentrations were determined. Febuxostat pharmacokinetics were estimated using a two-compartment model with first-order absorption. An Emax PK-PD model was fitted to mean febuxostat and urate concentrations. Urinary urate excretion and FCU were calculated pre- and post-dose.

Results

Maximum mean plasma concentration of febuxostat (2.7 mg L

SUBMITTER: Kamel B 

PROVIDER: S-EPMC7688545 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature