Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior.

ABSTRACT: Lysyl oxidase-like-1 (LOXL1), a vital crosslinking enzyme in elastin fiber maintenance, is essential for the stability and strength of elastic vessels and tissues. Variants in the LOXL1 locus associate with a dramatic increase in risk of exfoliation syndrome (XFS), a systemic fibrillopathy, which often presents with ocular hypertension and exfoliation glaucoma (XFG). We examined the role of LOXL1 in conventional outflow function, the prime regulator of intraocular pressure (IOP). Using Loxl1^-/- , Loxl1^+/- , and Loxl1^+/+ mice, we observed an inverse relationship between LOXL1 expression and IOP, which worsened with age. Elevated IOP in Loxl1^-/- mice was associated with a larger globe, decreased ocular compliance, increased outflow facility, extrac

SUBMITTER: Li G 

PROVIDER: S-EPMC7688556 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature