Gestational diabetes induces behavioral and brain gene transcription dysregulation in adult offspring.

ABSTRACT: The etiology of Autism Spectrum Disorders (ASD) includes a strong genetic component and a complicated environmental component. Recent evidence indicates that maternal diabetes, including gestational diabetes, is associated with an increased prevalence of ASD. While previous studies have looked into possible roles for maternal diabetes in neurodevelopment, there are few studies into how gestational diabetes, with no previous diabetic or metabolic phenotype, may affect neurodevelopment. In this study, we have specifically induced gestational diabetes in mice, followed by behavioral and molecular phenotyping of the mice offspring. Pregnant mice were injected with STZ a day after initiation of pregnancy. Glucose levels increased to diabetic levels between E7 and E14 in pregnancy in a subset of

SUBMITTER: Aviel-Shekler K 

PROVIDER: S-EPMC7688640 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature