An epigenome-wide association study of metabolic syndrome and its components.

ABSTRACT: The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate knowledge of the pathological mechanisms behind the condition at the methylation level, we conducted an epigenome-wide association study (EWAS) of MetS and its components, testing 1187 individuals of European ancestry for approximately 470 000 methylation sites throughout the genome. Methylation site cg19693031 in gene TXNIP -previously associated with type 2 diabetes, glucose and lipid metabolism, associated with fasting glucose level (P = 1.80 × 10^-8). Cg06500161 in gene ABCG1 associated both with serum triglycerides (P = 5.36 × 10^-9) and waist circumference (P = 5.21 × 10^-9). The previously identified typ

SUBMITTER: Nuotio ML 

PROVIDER: S-EPMC7688654 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature