Does Maternal Normal Range Thyroid Function Play a Role in Offspring Birth Weight? Evidence From a Mendelian Randomization Analysis.

ABSTRACT:

Background

The association between normal range thyroid function and offspring birth weight has been postulated, but evidence from observational studies is prone to be confounded. We conducted a two-sample Mendelian randomization (MR) study to explore the causal effects of maternal thyroid stimulating hormone (TSH) and free thyroxine (FT4) on birth weight.

Methods

We utilized public shared summary-level statistics from European-ancestry genome wide association studies. We obtained 40 and 21 single nucleotide polymorphisms as instrumental variables, which were associated with TSH and FT4 levels at genome-wide significance (P < 5 × 10^-8). Partitioned maternal effects on birth weight were retrieved from datasets contributed by the Early Growth Genetics Consort

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7689005 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature