Drugs used to induce fetal demise prior to abortion: a systematic review.

ABSTRACT: Clinicians have used feticidal agents prior to second trimester abortion for many years. Despite the widespread use of various agents to induce fetal demise, a comprehensive or systematic review of the evidence is lacking on the safety, effectiveness, and most effective routes of administration.

Objectives

To evaluate the existing drugs and routes of administration used in inducing fetal demise prior to abortion, and to determine the safety, effectiveness, and acceptability of these feticidal agents.

Methods

We searched PubMed, EMBASE, CINAHL, POPLINE, and Global Index Medicus to identify studies describing pharmacologic agents used to induce fetal demise prior to termination of pregnancy. We included randomized controlled trials and observational studies comparing digoxin, p

SUBMITTER: Tufa TH 

PROVIDER: S-EPMC7689273 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature