Impact of Long Non-coding RNAs Associated With Microenvironment on Survival for Bladder Cancer Patients.

ABSTRACT:

Background

Cumulative evidence from several tumor studies, including bladder cancer, emphasizes the importance of the tumor microenvironment (TME) in tumorigenesis, development, and metastasis, which can be regulated by long non-coding RNAs (lncRNAs). This study aims to identify bladder cancer (BC) microenvironment-associated lncRNAs for their prognostic value predicting the survival of BC patients.

Methods

The data of BC patients regarding lncRNA expression and corresponding clinical characteristics were obtained from The Cancer Genome Atlas (TCGA). The Cox regression analysis and the least absolute shrinkage and selection operator (LASSO) regression analysis were performed to screen lncRNAs following the calculation of the immune score for each sample. For the screened lnc

SUBMITTER: Lin G 

PROVIDER: S-EPMC7689372 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature