Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma.

ABSTRACT:

Introduction

Reasons why pancreatic ductal adenocarcinoma (PDAC) continues to have poor survival are only partly known. No previous studies have analyzed the combined influence of KRAS mutations, persistent organic pollutants (POPs), and trace elements upon survival in PDAC or in any other human cancer.

Objective

To analyze the individual and combined influence of KRAS mutations, POPs, and trace elements upon survival from PDAC.

Methods

Incident cases of PDAC (n = 185) were prospectively identified in five hospitals in Eastern Spain in 1992-1995 and interviewed face-to-face during hospital admission. KRAS mutational status was determined from tumour tissue through polymerase chain reaction and artificial restriction fragment length polymorphism. Blood and toenail samp

SUBMITTER: Porta M 

PROVIDER: S-EPMC7689512 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature