Label-free X-ray estimation of brain amyloid burden.

ABSTRACT: Amyloid plaque deposits in the brain are indicative of Alzheimer's and other diseases. Measurements of brain amyloid burden in small animals require laborious post-mortem histological analysis or resource-intensive, contrast-enhanced imaging techniques. We describe a label-free method based on spectral small-angle X-ray scattering with a polychromatic beam for in vivo estimation of brain amyloid burden. Our findings comparing 5XFAD versus wild-type mice correlate well with histology, showing promise for a fast and practical in vivo technique.

SUBMITTER: Dahal E 

PROVIDER: S-EPMC7689528 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature