Association of Low Plasma Transthyretin Concentration With Risk of Heart Failure in the General Population.

ABSTRACT:

Importance

Several lines of evidence support low plasma transthyretin concentration as an in vivo biomarker of transthyretin tetramer instability, a prerequisite for the development of both wild-type transthyretin cardiac amyloidosis (ATTRwt) and hereditary transthyretin cardiac amyloidosis (ATTRm). Both ATTRm and ATTRwt cardiac amyloidosis may manifest as heart failure (HF). However, whether low plasma transthyretin concentration confers increased risk of incident HF in the general population is unknown.

Objective

To evaluate whether low plasma transthyretin concentration is associated with incident HF in the general population.

Design, setting, and participants

This study included data from 2 similar prospective cohort studies of the Danish general population, the C

SUBMITTER: Greve AM 

PROVIDER: S-EPMC7689572 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature