The requirement for cobalt in vitamin B₁₂: A paradigm for protein metalation.

ABSTRACT: Vitamin B₁₂, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that represents one of the most complex small molecules made by nature. In prokaryotes it is utilised as a cofactor, coenzyme, light sensor and gene regulator yet has a restricted role in assisting only two enzymes within specific eukaryotes including mammals. This deployment disparity is reflected in another unique attribute of vitamin B₁₂ in that its biosynthesis is limited to only certain prokaryotes, with synthesisers pivotal in establishing mutualistic microbial communities. The core component of cobalamin is the corrin macrocycle that acts as the main ligand for the cobalt. Within this review we investigate why cobalt is paired specifically with the corrin ring, how cobalt is in

SUBMITTER: Osman D 

PROVIDER: S-EPMC7689651 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature