Identification of Antitumor Active Constituents in Polygonatum sibiricum Flower by UPLC-Q-TOF-MS^E and Network Pharmacology.

ABSTRACT: We aimed to investigate the material basis and mechanisms underlying the antitumor activity of Polygonatum sibiricum flower by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS^E). A compound-protein interaction network for cancer was constructed to identify potential drug targets, and then the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was conducted to elucidate the pathways involved in the antitumor activity of P. sibiricum flower. Subsequently, molecular docking was performed to determine whether the identified proteins are a target of the compounds of P. sibiricum flower. Sixty-four compounds were identified in P. sibiricum flower. Among these, 35 active constituents and 72 corre

SUBMITTER: Huang ZZ 

PROVIDER: S-EPMC7689665 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature