Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM.

ABSTRACT: Progenitor cells are crucial in controlling organ morphogenesis. Tooth development is a well-established model for investigating the molecular and cellular mechanisms that regulate organogenesis. Despite advances in our understanding of how tooth crown formation is regulated, we have limited understanding of tooth root development. Runt-related transcription factor 2 (RUNX2) is a well-known transcription factor in osteogenic differentiation and early tooth development. However, the function of RUNX2 during tooth root formation remains unknown. We revealed in this study that RUNX2 is expressed in a subpopulation of GLI1+ root progenitor cells, and that loss of Runx2 in these GLI1+ progenitor cells and their progeny results in root developmental defects. Our results provide in vivo evidence

SUBMITTER: Wen Q 

PROVIDER: S-EPMC7689689 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature