Etiologic heterogeneity of clear-cell and papillary renal cell carcinoma in the Netherlands Cohort Study.

ABSTRACT: At present, mostly case-control and retrospective studies have investigated the association between etiologic risk factors and the development of histologic subtypes of renal cell carcinoma (RCC). Therefore, we assessed the heterogeneity between body mass index (BMI), cigarette smoking, alcohol consumption and hypertension across clear-cell RCC (ccRCC) and papillary RCC (pRCC) risk in the prospective Netherlands Cohort Study on diet and cancer. In 1986, 120 852 participants aged 55 to 69 completed a self-administered questionnaire on diet and other risk factors for cancer. Participants were followed up for cancer through record linkage. Tumor histology was assessed through centralized revision by two experienced uropathologists. After 20.3 years of follow-up, 384 histologically verified RC

SUBMITTER: van de Pol JAA 

PROVIDER: S-EPMC7689694 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature