Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation.

ABSTRACT:

Background & aims

Endoplasmic reticulum (ER) stress is one of the major causes of hepatic insulin resistance through increasing de novo lipogenesis. Forkhead box O6 (FoxO6) is a transcription factor mediating insulin signalling to glucose and lipid metabolism, therefore, dysregulated FoxO6 is involved in hepatic insulin resistance. In this study, we elucidated the role of FoxO6 in ER stress-induced hepatic lipogenesis.

Methods

Hepatic ER stress responses and lipogenesis were monitored in mice overexpressed with constitutively active FoxO6 allele and FoxO6-null mice. In the in vitro study, HepG2 cells overexpressing constitutively active FoxO6 were treated with palmitate, and then alterations in ER stress and lipid metabolism were measured.

Results

FoxO6 activation ind

SUBMITTER: Kim DH 

PROVIDER: S-EPMC7689817 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature