Semaglutide once weekly in people with type 2 diabetes: Real-world analysis of the Canadian LMC diabetes registry (SPARE study).

ABSTRACT:

Aims

To investigate real-world short-term clinical outcomes in adults with type 2 diabetes (T2D) who initiated semaglutide in a specialist endocrinology practice in Canada.

Materials and methods

This study was a retrospective observational study using data from the Canadian LMC Diabetes Registry. Adults with T2D who were naïve to glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy, initiated semaglutide therapy as usual standard of care between February 2018 and February 2019, and maintained semaglutide therapy during follow-up, were eligible for analysis. The primary outcome was mean change in glycated haemoglobin (HbA1c) at 3- to 6-month follow-up.

Results

In the final analytical cohort (n = 937), there was a statistically significant mean ± SD reduction in H

SUBMITTER: Brown RE 

PROVIDER: S-EPMC7689820 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature