Structure-function relation of the developing calyx of Held synapse in vivo.

ABSTRACT:

Key points

During development the giant, auditory calyx of Held forms a one-to-one connection with a principal neuron of the medial nucleus of the trapezoid body. While anatomical studies described that most of the target cells are temporarily contacted by multiple calyces, multi-calyceal innervation was only sporadically observed in in vivo recordings, suggesting a structure-function discrepancy. We correlated synaptic strength of inputs, identified in in vivo recordings, with post hoc labelling of the recorded neuron and synaptic terminals containing vesicular glutamate transporters (VGluT). During development only one input increased to the level of the calyx of Held synapse, and its strength correlated with the large VGluT cluster contacting the postsynaptic soma. As neither co

SUBMITTER: Sierksma MC 

PROVIDER: S-EPMC7689866 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature