Modular and Versatile Trans-Encoded Genetic Switches.

ABSTRACT: Current bacterial RNA switches suffer from lack of versatile inputs and are difficult to engineer. We present versatile and modular RNA switches that are trans-encoded and based on tRNA-mimicking structures (TMSs). These switches provide a high degree of freedom for reengineering and can thus be designed to accept a wide range of inputs, including RNA, small molecules, and proteins. This powerful approach enables control of the translation of protein expression from plasmid and genome DNA.

SUBMITTER: Paul A 

PROVIDER: S-EPMC7689881 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature