Antibacterial Porous Electrospun Fibers as Skin Scaffolds for Wound Healing Applications.

ABSTRACT: Electrospun fiber scaffolds have a huge potential for the successful treatment of infected wounds based on their unique properties. Although several studies report novel drug-loaded electrospun fiber-based biomaterials, many of these do not provide information on their interactions with eukaryotic and bacterial cells. The main aim of this study was to develop antibacterial drug-loaded porous biocompatible polycaprolactone (PCL) fiber scaffolds mimicking the native extracellular matrix for wound healing purposes. Mechanical property evaluation and different biorelevant tests were conducted in order to understand the structure-activity relationships and reveal how the surface porosity of fibers and the fiber diameter affect the scaffold interactions with the living bacterial and eukaryotic f

SUBMITTER: Lanno GM 

PROVIDER: S-EPMC7689890 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature