Novel Synthesis and Antiviral Evaluation of New Benzothiazole-Bearing N-Sulfonamide 2-Pyridone Derivatives as USP7 Enzyme Inhibitors.

ABSTRACT: In this article, a series of benzothiazole-bearing N-sulfonamide 2-pyridone derivatives were synthesized via the reaction of benzothiazole sulfonylhydrazide with sodium salts of both (hydroxymethylene) cycloalkanones and unsaturated ketones, as well as ethoxymethylene derivatives. The structures of the resultant compounds were confirmed using IR, ¹H NMR, ¹³C NMR, ¹H-¹H correlation spectroscopy (COSY), ¹H-¹³C heteronuclear multiple bond coherence (HMBC), and ¹H-¹³C heteronuclear multiple quantum coherence (HSQC) spectral analysis and elemental analysis. The newly synthesized compounds were evaluated in vitro for their antiviral activities against the HSV-1, HAV HM175, HCVcc genotype 4, CBV4, and H

SUBMITTER: Azzam RA 

PROVIDER: S-EPMC7689895 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature