Multi-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome.

ABSTRACT:

Background

Q fever fatigue syndrome (QFS) is characterised by a state of prolonged fatigue that is seen in 20% of acute Q fever infections and has major health-related consequences. The molecular mechanisms underlying QFS are largely unclear. In order to better understand its pathogenesis, we applied a multi-omics approach to study the patterns of the gut microbiome, blood metabolome, and inflammatory proteome of QFS patients, and compared these with those of chronic fatigue syndrome (CFS) patients and healthy controls (HC).

Methods

The study population consisted of 31 QFS patients, 50 CFS patients, and 72 HC. All subjects were matched for age, gender, and general geographical region (South-East part of the Netherlands). The gut microbiome composition was assessed by Metagen

SUBMITTER: Raijmakers RPH 

PROVIDER: S-EPMC7690002 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature