The prognostic role of plasma fibrinogen in adult secondary hemophagocytic lymphohistiocytosis.

ABSTRACT:

Background

In adult patients with secondary hemophagocytic lymphohistiocytosis (sHLH), no valid immune biomarker has been available for predicting the prognosis of untreated sHLH patients.

Methods

Circulating plasma levels of fibrinogen (FIB) were measured at diagnosis in 293 cases of adult sHLH. We categorized FIB levels into tertiles. Multivariable Cox proportional hazards models were used to evaluate the relationship between FIB and survival. Restricted cubic spline models and two-piecewise Cox proportional hazards models were used to address the nonlinear association between FIB and mortality.

Results

During a median follow-up of 52 (interquartile ranges, 18-221) days, 208 deaths occurred, with 137 deaths in malignancy-associated hemophagocytic lymphohistiocytosis

SUBMITTER: Yin G 

PROVIDER: S-EPMC7690012 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature