Light-Activated Signaling in DNA-Encoded Sender-Receiver Architectures.

ABSTRACT: Collective decision making by living cells is facilitated by exchange of diffusible signals where sender cells release a chemical signal that is interpreted by receiver cells. A variety of nonliving artificial cell models have been developed in recent years that mimic various aspects of diffusion-based intercellular communication. However, localized secretion of diffusive signals from individual protocells, which is critical for mimicking biological sender-receiver systems, has remained challenging to control precisely. Here, we engineer light-responsive, DNA-encoded sender-receiver architectures, where protein-polymer microcapsules act as cell mimics and molecular communication occurs through diffusive DNA signals. We prepare spatial distributions of sender and receiver protocells using a

SUBMITTER: Yang S 

PROVIDER: S-EPMC7690052 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature