Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight loss over 52 weeks was associated with FVC decline, or influenced the effect of nintedanib, in patients with IPF.

Methods

Using pooled data from the two INPULSIS trials, we analysed the rate of decline in FVC (mL/yr) over 52 weeks in patients treated with nintedanib and placebo in subgroups by baseline BMI (< 25; ≥25 to < 30; ≥30 kg/m²) and by weight loss over 52 weeks (≤5; > 5%) using random coefficient regression.

Results

In the placebo grou

SUBMITTER: Jouneau S 

PROVIDER: S-EPMC7690188 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature