Clinical, molecular, and radiomic profile of gliomas with FGFR3-TACC3 fusions.

ABSTRACT:

Background

Actionable fibroblast growth factor receptor 3 (FGFR3)-transforming acidic coiled-coil protein 3 fusions (F3T3) are found in approximately 3% of gliomas, but their characteristics and prognostic significance are still poorly defined. Our goal was to characterize the clinical, radiological, and molecular profile of F3T3 positive diffuse gliomas.

Methods

We screened F3T3 fusion by real-time (RT)-PCR and FGFR3 immunohistochemistry in a large series of gliomas, characterized for main genetic alterations, histology, and clinical evolution. We performed a radiological and radiomic case control study, using an exploratory and a validation cohort.

Results

We screened 1162 diffuse gliomas (951 unselected cases and 211 preselected for FGFR3 protein immunopositivity),

SUBMITTER: Di Stefano AL 

PROVIDER: S-EPMC7690363 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature