Diverse Horizontally-Acquired Gene Clusters Confer Sucrose Utilization to Different Lineages of the Marine Pathogen Photobacterium damselae subsp. damselae.

ABSTRACT: The ability to metabolize sucrose is a variable trait within the family Vibrionaceae. The marine bacterium Photobacterium damselae subsp. damselae (Pdd), pathogenic for marine animals and humans, is generally described as negative for sucrose utilization (Scr^-). Previous studies have reported sucrose-utilizing isolates (Scr⁺), but the genetic basis of this variable phenotype remains uncharacterized. Here, we carried out the genome sequencing of five Scr⁺ and two Scr^- Pdd isolates and conducted a comparative genomics analysis with sixteen additional Pdd genomes sequenced in previous studies. We identified two different versions of a four-gene cluster (scr cluster) exclusive of Scr⁺ isolates encoding a PTS system sucrose-specific IIBC co

SUBMITTER: Abushattal S 

PROVIDER: S-EPMC7690375 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature