Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial?

ABSTRACT: Epilepsy is a common neurological disorder which affects patients physically and mentally and causes a real burden for the patient, family and society both medically and economically. Currently, more than one-third of epilepsy patients are still under unsatisfied control, even with new anticonvulsants. Other measures may be added to those with drug-resistant epilepsy. Excessive neuronal synchronization is the hallmark of epileptic activity and prolonged epileptic discharges such as in status epilepticus can lead to various cellular events and result in neuronal damage or death. Unbalanced oxidative status is one of the early cellular events and a critical factor to determine the fate of neurons in epilepsy. To counteract excessive oxidative damage through exogenous antioxidant supplements

SUBMITTER: Lin TK 

PROVIDER: S-EPMC7690410 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature