Dataset Information

A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.

ABSTRACT:

Background

Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes their clinical application.

Objective

To achieve an international consensus on MIBC molecular subtypes that reconciles the published classification schemes.

Design, setting, and participants

We used 1750 MIBC transcriptomic profiles from 16 published datasets and two additional cohorts.

Outcome measurements and statistical analysis

We performed a network-based analysis of six independent MIBC classification systems to identify a consensus set of molecular classes. Association with survival was assessed using multivariable Cox models.